Author(s)

Mohamed Mohamed Soliman, Mohamed Mohamed Ahmed, Samir Ahmed El-Shazly, Tamer Ahmed Ismail, Hossam Fouad Attia, Ahmed Farag Elkirdasy

Department of Biochemistry, College of Veterinary Medicine, University of Sadat City, Sadat City, Egypt; Department of Biomedical Sciences, Shaqraa University, College of Pharmacy, Shaqraa, Saudi Arabia.
Department of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia; Department of Biochemistry, College of Veterinary Medicine, Kaferel-sheikh University, Kafer El-Sheikh, Egypt.
Department of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia; Department of Biochemistry, College of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
Medical Laboratory Department, College of Applied Medical Sciences, Taif University, Turabah, Saudi Arabia; Department of Biochemistry, College of Veterinary Medicine, Benha University, Banha, Egypt.
Medical Laboratory Department, College of Applied Medical Sciences, Taif University, Turabah, Saudi Arabia; Department of Histology, College of Veterinary Medicine, Benha Uni-versity, Banha, Egypt.
Medical Laboratory Department, College of Applied Medical Sciences, Taif University, Turabah, Saudi Arabia; Department of Physiology, College of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

In the present study, we investigated the biochemical alterations and gene expression of carbohydrate and lipid metabolism after oral administration of vitamin A and E for 2 months in diet-induced obese Wistar rats. Vitamin A and E administration reduced significantly the increase in body weight and food intake and normalized the alterations in lipid profiles in obese rats compared to normal rats. Moreover, both vitamins decreased the fat accumulation in liver tissues of obese rats. Finally, they up-regulated mRNA expression of Pyruvate Kinase (PK) and Glucose Transporter-2 (GLUT-2), and increased lipolysis and cholesterol metabolism through up-regulation of lipoprotein lipase (LPL), Sterol Responsible Element Binding Protein-1a (STREBP-1a) and STREBP-1c mRNA expression. In conclusion, vitamin A and E regulate gene expression of carbohydrate and lipid metabolism, and also ameliorate changes associated with obesity induced by high fat diet in Wistar rats.

Vitamin A and E; Lipid Metabolism; Carbohydrate Metabolism; Gene Regulation; Wistar Rats

Soliman, M. , Ahmed, M. , El-Shazly, S. , Ismail, T. , Attia, H. and Elkirdasy, A. (2014) Effect of vitamin A and E on carbohydrate and lipid metabolism in diet-induced obese wistar rats. Advances in Bioscience and Biotechnology, 5, 4-11. doi: 10.4236/abb.2014.51002.