Green and Sustainable Chemistry

Volume 1, Issue 1 (February 2011)

ISSN Print: 2160-6951   ISSN Online: 2160-696X

Google-based Impact Factor: 0.71  Citations  

The Synergy of Combined Use of DMSO and Bronsted Acid (Ionic Liquid) as a Catalyst Part I: Efficient Niementowski Synthesis of Modified Quinazolinones

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DOI: 10.4236/gsc.2011.11003    6,126 Downloads   14,268 Views  Citations

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ABSTRACT

A new rapid and versatile approach using Ionic liquid/DMSO as a chemical reagent for the synthesis of fused heterocyclic compounds in a highly efficient way is described. This method offers the advantages of proceeding in neutral conditions, giving high to excellent isolated yields (83–92%) for Niementowski synthesis with easy workup procedure. The inherent Bronsted acidity of ionic liquid and high polarity of both IL and DMSO resulted in a significant enhancement in the reaction rate.

Share and Cite:

M. Kathiravan, R. Jalnapurkar, T. Chitre, R. Tamboli and K. Srinivasan, "The Synergy of Combined Use of DMSO and Bronsted Acid (Ionic Liquid) as a Catalyst Part I: Efficient Niementowski Synthesis of Modified Quinazolinones," Green and Sustainable Chemistry, Vol. 1 No. 1, 2011, pp. 12-18. doi: 10.4236/gsc.2011.11003.

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