Morphological abnormalities in Drosophila with overexpression of human APP gene - Open Journal of Animal Sciences

OJAS > Vol.3 No.4, November 2013

Open Journal of Animal Sciences

Volume 3, Issue 4 (November 2013)

ISSN Print: 2161-7597 ISSN Online: 2161-7627

Google-based Impact Factor: 1.39 Citations h5-index & Ranking

Morphological abnormalities in Drosophila with overexpression of human APP gene ()

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DOI: 10.4236/ojas.2013.34A2006 2,901 Downloads 4,903 Views

Author(s)

Dmitry Rodin, Olga Bolshakova, Galina Kislik, Svetlana Sarantseva

Affiliation(s)

Molecular and Radiation Biophysics Department, National Research Centre “Kurchatov Institute”-B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia.
Molecular and Radiation Biophysics Department, National Research Centre “Kurchatov Institute”-B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia;.

ABSTRACT

Alzheimer’s disease (AD) is the leading and one of the most severe forms of dementia. Molecular mechanisms underlying AD pathogenesis despite much work on this subject still remain unclear. Cleavage of amyloid precursor protein (APP) to amyloid beta peptide (A-beta) and following formation of amyloid plaques are the key events of Alzheimer’s pathology. Thus changes in APP expression and metabolism can lead to pathology development. Here we show that overexpression of human APP in Drosophila neural cells manifests in different morphological abnormalities of Drosophila imago that can be observed immediately after fly eclosion. This observation can help to further understand APP molecular functions and its participation in different molecular pathways.

KEYWORDS

Alzheimer’s Disease; Drosophila; Amyloid Precursor Protein; Morphological Abnormalities

Share and Cite:

Rodin, D. , Bolshakova, O. , Kislik, G. and Sarantseva, S. (2013) Morphological abnormalities in Drosophila with overexpression of human APP gene. Open Journal of Animal Sciences, 3, 49-52. doi: 10.4236/ojas.2013.34A2006.

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