Author(s)

Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar

Department of Chemistry, Faculty of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, KSA.
Department of Chemistry, Faculty of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, KSA Photochemistry Department, Heterocyclic & Nucleosides Unit, National Research Centre, Cairo, Egypt.

A new and efficient procedure has been designed for the preparation of 6-arylmethylene-amino-2-alkyl sulfonyl-pyrimidine. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully achieved using the phosphorous oxychloride method to afford 4-chloro-2-alkylthio-pyrimidines. Subsequent nucleophilic displacement by the corresponding alkylamines followed by glycoside bromide addition conveniently gave a series of the target compounds. Thus, the two same or different alkylamino groups were easily introduced into the pyrimidine ring through the two different approaches. The human anti-platelet aggregation activity of the newly synthesized compounds was also described.

Natural Asset; Financial Value; Neural Network

Alshammari, A. and El-Gazzar, A. (2013) Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its Nucleosides. International Journal of Organic Chemistry, 3, 28-40. doi: 10.4236/ijoc.2013.33A004.