The represent paper will study the performance of the power plant with the combination of dry and wet cooling systems in different operating conditions. A thermodynamic performance analysis of the steam cycle system was performed by means of a program code dedicated to power plant modeling in design operating condition. Then the off-design behavior was studied by varying not only the ambient temperature and relative humidity but also several parameters connected to the cooling performance, like the exhaust steam flow rate, the air cooling fan load and the number of operating cooling water pumps and cooling towers. The result is an optimum set of variables allowing the dry and wet cooling system be regulated in such a way that the maximum power is achieved and low water consumption.