Microarray data analysis: Gaining biological insights - Journal of Biomedical Science and Engineering

JBiSE > Vol.6 No.10, October 2013

Journal of Biomedical Science and Engineering

Volume 6, Issue 10 (October 2013)

ISSN Print: 1937-6871 ISSN Online: 1937-688X

Google-based Impact Factor: 0.66 Citations h5-index & Ranking

Microarray data analysis: Gaining biological insights ()

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Download as PDF (Size: 1062KB) PP. 996-1005

DOI: 10.4236/jbise.2013.610124 4,452 Downloads 7,279 Views Citations

Author(s)

Rumdeep Kaur Grewal, Sampa Das

Affiliation(s)

Division of Plant Biology, Bose Institute, Kolkata, India.

ABSTRACT

DNA microarray is a widely used technique which allows one to identify the genes that are similarly or differentially expressed in different cell types or conditions, to learn how their expression levels change in different developmental stages or disease states, and to identify the cellular processes in which they participate. This technology produces a large amount of complex data, necessitating employment of multiple bioinformatics and computational tools and techniques to provide a comprehensive view of the underlying biology. This review overviews methods and techniques which may be employed to analyze and interpret microarray data. The focus is primarily on analysis of gene expression matrices to obtain biological insights to this end. Both supervised and unsupervised methods commonly used for expression data analysis have been discussed. Data visualization techniques which may be used to comprehend biological relevance of the data has also been discussed in brief.

KEYWORDS

Microarray; Cluster; Pathway; Network

Share and Cite:

Grewal, R. and Das, S. (2013) Microarray data analysis: Gaining biological insights. Journal of Biomedical Science and Engineering, 6, 996-1005. doi: 10.4236/jbise.2013.610124.

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