Journal of Cancer Therapy
Volume 4, Issue 7 (September 2013)
ISSN Print: 2151-1934 ISSN Online: 2151-1942
Google-based Impact Factor: 0.30 Citations h5-index & Ranking
Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis ()
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ABSTRACT
In patients with epithelian ovarian cancer who have achieved remission after initial surgery and induction chemotherapy, the role of maintenance chemotherapy is controversial. We carried out a trial-sequential analysis that included 4 randomised controlled trials. The end-point was progression at 3 years while the boundary for non-inferiority was set at ±20% in risk ratio. The results of our trial-sequential analysis indicated the futility of maintenance chemotherapy, i.e. proof of no effectiveness. Consequently, no further trials of this type should be performed to assess the effectiveness of this intervention in this clinical condition.
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