Pharmacology & Pharmacy

Volume 2, Issue 1 (January 2011)

ISSN Print: 2157-9423   ISSN Online: 2157-9431

Google-based Impact Factor: 0.70  Citations  h5-index & Ranking

Microwave Assisted Synthesis and Evaluation of Cross-Linked Carboxymethylated Sago Starch as Superdisintegrant

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DOI: 10.4236/pp.2011.21005    6,493 Downloads   14,535 Views  Citations

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ABSTRACT

The aim of this study was to modify the sago starch and evaluate its efficacy as tablet disintegrant. Cross-linked car-boxymethylated sago starch (CMSS) was synthesized using native sago starch (SS) and monochloroacetic acid (MCA) with sodium hydroxide in microwave radiation environment. FT-IR analysis of the sample confirmed the carboxy-methylation by showing absorption peak at 1607.2 cm-1. CMSS with degree of substitution (DS) of 0.31 was formed and, it was further evaluated as disintegrant in Ondasetron based tablets. The results revealed that CMSS could be used as disintegrant in tablet formulation in concentration dependant manner.

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A. Singh, L. Nath, M. Guha and R. Kumar, "Microwave Assisted Synthesis and Evaluation of Cross-Linked Carboxymethylated Sago Starch as Superdisintegrant," Pharmacology & Pharmacy, Vol. 2 No. 1, 2011, pp. 42-46. doi: 10.4236/pp.2011.21005.

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