Cytogenetic abnormalities in 200 male infertile cases in the southern region of India - Open Journal of Genetics

OJGen > Vol.3 No.2, August 2013

Open Journal of Genetics

Volume 3, Issue 2 (August 2013)

ISSN Print: 2162-4453 ISSN Online: 2162-4461

Google-based Impact Factor: 0.21 Citations

Cytogenetic abnormalities in 200 male infertile cases in the southern region of India ()

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DOI: 10.4236/ojgen.2013.32A3005 4,733 Downloads 7,806 Views Citations

Author(s)

G. Sreenivasa, Suttur S. Malini, Prasanna Kumari, Usha R. Dutta

Affiliation(s)

Department of Pathology (Cytogenetics), Kidwai Memorial Institute of Oncology, Bangalore, India.
Diagnostics Division, Center for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India.
Molecular Reproductive and Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Mysore, India.

ABSTRACT

Chromosomal abnormalities are one of the major causes of male infertility. But the exact mechanism by which chromosomal anomalies induces infertility is still not clear. Many studies have documented the chromosomal abnormalities ranging from 2.2% to 15.7% in infertile men. The present study has been carried out to document and find out the genetic cause of male infertility in the Southern region of India. The cytogenetic analysis of 200 male infertile cases, referred due to primary infertility from 2009 to 2012, were analyzed by GTG banding and evaluated retrospectively. The semen analysis was also performed. A total of 15 cases (7.5%) showed chromosomal aberrations. Four (2%) were 47, XXY and mosaic 47,XXY; Two (1%) were structural autosomal abnormalities; Two (1%) were inversion Y; Seven (3.5%) cases were Y heterochromatin variants and 185 cases (92.5%) showed normal 46,XY karyotype. The chromosomal abnormalities in our study is also in agreement with the data from the literature. Also abnormal spermatogenesis is observed in these cases. Apart from chromosomal analysis further in depth molecular analysis and genetic counseling is suggestive in such cases, especially those interested in IVF technologies.

KEYWORDS

Male Infertility; Chromosomal Abnormalities; Semen Analysis

Share and Cite:

Sreenivasa, G. , Malini, S. , Kumari, P. and Dutta, U. (2013) Cytogenetic abnormalities in 200 male infertile cases in the southern region of India. Open Journal of Genetics, 3, 33-37. doi: 10.4236/ojgen.2013.32A3005.

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