For the seventies, scientists focused their researches to find techniques to produce high quality films. One of the ideas, for example, was to generate an ionized cluster beam (ICB) formed by inert gas condensation (IGC) from evaporation of material. This method generates non-agglomerated nanoparticles to be deposited onto any substrate. However, the synthesis of spherical and well-dispersed nanoparticles remains, today, a major technological issue. Several trials have been performed with magnetron sputtering that has the advantage of producing very pure atomic vapour from a wide variety of solid materials or composites, and therefore in this configuration offers the possibility to synthesize nanoparticles in a gaz phase with potential numerous applications. In this paper, we describe several results of our laboratory and we show how it is possible to synthesize non-agglomerated nanoparticles with a narrow size distribution in the nm range. Detailed examples of Ag, TiO₂, Au, Y, C, Co and Fe are given. We illustrate their current use in applications including catalyst to produce aligned Multi-Wall Carbon Nanotubes, seeding layer to promote anatase TiO₂ crystallisation for photocatalytic material, superhydrophobic material and nanoparticle for nanomedecine.