Journal of Cancer Therapy

Volume 4, Issue 5 (July 2013)

ISSN Print: 2151-1934   ISSN Online: 2151-1942

Google-based Impact Factor: 0.30  Citations  h5-index & Ranking

Time Elapsed from AML Diagnosis to Induction Chemotherapy Affects Overall Survival

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DOI: 10.4236/jct.2013.45108    3,627 Downloads   5,396 Views  Citations

ABSTRACT

We aimed to study the effect of elapsed time from AML diagnosis to treatment (TDT) on OS in a group of patients from public Hospital in Brazil. 41 AML (23 M, 18 F, 41 yrs, 18 - 84 yrs, from 2001 to 2004). There were 38 de novo AML and 3 secondary, median TDT was 6 days (range 1 - 82 d); the young ones were treated earlier than old ones (TDT 4 days vs 11, p = 0.07). Longer TDT (>10 d) was associated with worse CR rates (p = 0.02) and OS (p = 0.04). When patients were categorized into TDT from 1 - 4 d (I) vs >5 (II), those from I presented better OS than II (p = 0.004). When TDT was longer than 7 days OS decreased even more. Hb was higher in patients with TDT I vs II (8.3 vs 7.5 g/dL, p = 0.03) but WBC (p = 0.34) and platelet count (p = 0.75) were not different. Patients with TDT of 10 d were younger than TDT > 10 d (median age 41 vs 70 yrs, p = 0.001). The OS was 15.1% in 2 yrs and 8.6% in 7 yrs. Our data suggest longer TDT, when analyzed continuously, predicted for lower CR rates and OS rates.

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L. Pelloso, S. Rohr, M. Yamamoto and M. Chauffaille, "Time Elapsed from AML Diagnosis to Induction Chemotherapy Affects Overall Survival," Journal of Cancer Therapy, Vol. 4 No. 5, 2013, pp. 957-960. doi: 10.4236/jct.2013.45108.

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