Author(s)

Aurélie Lacoste, Jean-Benoît Corcuff, Antoine Benard, Sandy Leproust, Fabienne Nacka, Olivier Brissaud, Pascal Barat

CHU de bordeaux, Département de Pédiatrie, Réanimation Pédiatrique, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Département de Médecine Nucléaire, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.
Département de Pédiatrie, Centre d’Investigation Clinique (CIC 0005), Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Département de Pédiatrie, Endocrinologie Pédiatrique, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.
P?le de Santé Publique, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.

Background/aims: To determine whether the 17-hydroxyprogesterone (17-OHP)/cortisol ratio as a marker of immature11-beta hydroxylase activity can predict severe systemic hypotension in preterm neonates. Methods: Serum cortisol and 17-OHP concentrations were measured in capillary blood deposited on blotter paper on day 3 post-natal age (Day 3) in infants less than 32 weeks postmenstrual age (PMA). The predictive value of 17-OHP/cortisol ratio for a first episode of systemic hypotension occurring after Day 3 (FESH) was evaluated. Results: Of 105 infants included, 14 patients (13%) presented a FESH. Neither the 17-OHP/cortisol ratio, nor the 17-OHP or cortisol concentrations were associated with the occurrence of a FESH when adjusted for potential confounding factors. 17-OHP and cortisol were inversely associated to PMA (r = ﹣0.36 and ﹣0.40, respectively). Cortisol, but not 17-OHP, was associated with the type of hospitalization unit, the respiratory support and the presence of a patent ductus arteriosus. The 17-OHP/cortisol ratio was associated with the type of hospitalization unit only. Conclusions: The 17-OHP/ cortisol ratio at Day 3 did not predict the occurrence of a first episode of systemic hypotension after Day3 inpreterm neonates.

Relative Adrenal Insufficiency; Immaturity; Congenital Adrenal Hyperplasia Screening Program

Lacoste, A. , Corcuff, J. , Benard, A. , Leproust, S. , Nacka, F. , Brissaud, O. and Barat, P. (2013) Plasma 17-hydroxyprogesterone/cortisol ratio is not a predictor of systemic hypotension in extremely premature infants. Open Journal of Pediatrics, 3, 78-84. doi: 10.4236/ojped.2013.32015.