American Journal of Analytical Chemistry
Volume 4, Issue 1 (January 2013)
ISSN Print: 2156-8251 ISSN Online: 2156-8278
Google-based Impact Factor: 1.71 Citations h5-index & Ranking
Isolation and Characterization of S-Enantiomer in Montelukast ()
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ABSTRACT
A simple and rapid Supercritical Fluid Chromatography (SFC) Method has been developed to isolate and characterize the S-Isomer of Montelukast by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbon dioxide (CO2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H NMR. The purity of isolated S-Isomer is about 98%.
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