Red Blood Cell Mechanical Stability - Engineering

ENG > Vol.4 No.10, October 2012

Engineering

Volume 4, Issue 10 (October 2012)

ISSN Print: 1947-3931 ISSN Online: 1947-394X

Google-based Impact Factor: 0.66 Citations

Red Blood Cell Mechanical Stability ()

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DOI: 10.4236/eng.2012.410B003 4,987 Downloads 7,371 Views Citations

Author(s)

Oguz K. Baskurt

Affiliation(s)

Koc University School of Medicine Rumelifeneri Kampusu, Sariyer Istanbul, 34450, Turkey.

ABSTRACT

It has been well documented that shear forces effective above a certain magnitude under flow conditions causes damage in blood cells. This damage ranges from slight morphological alteration to the destruction of red blood cells (RBC). The hemolytic trauma to RBC can easily be detected by measuring free hemoglobin level in plasma, however there are no standardized protocols to quantitate subhemolytic trauma. Ektacytometry has been used to study the alterations in RBC mechanical properties induced by the application of shear stress at various levels. Additionally, a protocol for measuring the hemolytic threshold as an indicator of subhemolytic damage to RBC has been developed based on ektacytometry. These standardized protocols may find applications in the pre-clinical and clinical evaluation of artificial organs and biomedical devices contacting with blood.

KEYWORDS

Artificial Organs; Blood Damage; Subhemolytic Damage; Ektacytometry

Share and Cite:

O. Baskurt, "Red Blood Cell Mechanical Stability," Engineering, Vol. 4 No. 10B, 2012, pp. 8-10. doi: 10.4236/eng.2012.410B003.

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