Advances in Alzheimer's Disease

Volume 1, Issue 3 (December 2012)

ISSN Print: 2169-2459   ISSN Online: 2169-2467

Google-based Impact Factor: 0.81  Citations  

Spatial structure of beta-amyloid Aβ1-40 in complex with a biological membrane model

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DOI: 10.4236/aad.2012.13004    4,847 Downloads   9,282 Views  Citations

ABSTRACT

The spatial structure of beta-amyloid Aβ1-40 in complex with sodium dodecyl sulfate micelles as a model membrane system was investigated by 1H-1H two-dimensional NMR (TOCSY, NOESY) spectroscopy and molecular dynamic method calculations. On the basis of NOE and chemical shifts changes data, spatial structure of the complex beta-amyloid-model of the cell surface membrane was obtained.

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Usachev, K., Filippov, A., Antzutkin, O. and Klochkov, V. (2012) Spatial structure of beta-amyloid Aβ1-40 in complex with a biological membrane model. Advances in Alzheimer's Disease, 1, 22-29. doi: 10.4236/aad.2012.13004.

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