A Simple and Convenient Synthesis of Isolated-Fused Heterocycles Based on: 2-Imino-N-phenyl-2H-chromene-3-carboxamide - Open Journal of Synthesis Theory and Applications

OJSTA > Vol.1 No.3, October 2012

Open Journal of Synthesis Theory and Applications

Volume 1, Issue 3 (October 2012)

ISSN Print: 2168-1244 ISSN Online: 2168-1252

A Simple and Convenient Synthesis of Isolated-Fused Heterocycles Based on: 2-Imino-N-phenyl-2H-chromene-3-carboxamide ()

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DOI: 10.4236/ojsta.2012.13008 4,936 Downloads 11,443 Views Citations

Author(s)

Islam H. El Azab, Fawi M. Abd El Latif Abd El Latif

Affiliation(s)

Chemistry Department, Faculty of Science, South Valley University, Aswan, Egypt.

ABSTRACT

Starting from 2-imino-N-phenyl-2H-chromene-3-carbox-amide, (1) a series of functionalized chromenes were achieved; such as, 2-ethoxy-2,3-dihydro-3-phenylchromeno[2,3-d]pyrimidin-4-one (2), and 2-hydrazinyl-2,3-dihydro-3-phenylchromeno-[2,3-d]pyrimidin-4-one (3). Furthermore, reactions of (3) with some of laboratory available compounds gave pyrazoles (4-9, 12, 13a, 13b), tetrazoles (11), 2-(2-benzylidenehydrazinyl)-3-phenyl-3H-chromeno[2,3-d]pyrimidin4(10H)-oneisoxazoles (14), 5-chloro-1-(4-oxo-3-phenyl-4,10-dihydro-3H-chromeno[2,3-d]pyrimidin-2-yl)-3-phenyl-2, 3-dihydro-1H-pyrazole-4-carbonitrile (17), pyrimidines (28a, b), pyridines (29a-29e, 30, 33a, 33b), benzo[b][1, 4]oxazepin-2- amines (32a, b), 3-chloro-4-(2-imino-2H-chromen-3-yl)-1-phenyl-4-(phenylamino) azetidin-2-one (34a-34e) and 2-(2- imino-2H-chromen-3-yl)-3-phenyl-2-(phenyl amino)thiazolidin-4-onee (35a-35e). The structures of these compounds were established by elemental analysis, IR, MS and NMR spectral analysis.

KEYWORDS

2-Imino-2H-chromen-3-yl; Chromeno[2, 3-d]pyrimidin-4-one; β-Lactam; Thiazolidin-4-ones

Share and Cite:

El Azab, I. and Abd El Latif, F. (2012) A Simple and Convenient Synthesis of Isolated-Fused Heterocycles Based on: 2-Imino-N-phenyl-2H-chromene-3-carboxamide. Open Journal of Synthesis Theory and Applications, 1, 44-57. doi: 10.4236/ojsta.2012.13008.

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