Advances in Biological Chemistry

Volume 2, Issue 3 (August 2012)

ISSN Print: 2162-2183   ISSN Online: 2162-2191

Google-based Impact Factor: 0.5  Citations  

Analysis of the interaction between [Ru(phenanthroline)3]2+ and bovine serum albumin

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DOI: 10.4236/abc.2012.23033    7,225 Downloads   11,008 Views  Citations

ABSTRACT

The interaction of compounds with potential use as pharmaceutical with a carrier protein as serum albumin is of great importance in their biodistribution. Albumin offers different sites for binding metallic compounds. Using a combination of spectropho-tometric and electrochemical techniques, the interaction between [Ru(phen)3]Cl2 (phen = phenantroline) and bovine serum albumin was evaluated. In particular, it was possible to calculate an apparent binding constant (Kb) of 4.4 × 103 (for concentrations expressed in M) for the main interaction site of the protein. A number of ca. 40 molecules of Ru-phen per molecule of BSA under saturation conditions, and a positive cooperative behavior towards association from the protein were found.

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Luzuriaga, L. and Cerdá, M. (2012) Analysis of the interaction between [Ru(phenanthroline)3]2+ and bovine serum albumin. Advances in Biological Chemistry, 2, 262-267. doi: 10.4236/abc.2012.23033.

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