Author(s)

Lili Chen, Youzhi Li, Hongjian Zhu, Yuhua Liu, Bida Gao

Hunan Agricultural University, Changsha, Hunan, China.
Hunan Provicial University Key Lab for Plant Disease Control and Ulitization, Changsha, China.

Four groups of antibiotic activity compounds were separated and purified from the ethyl acetate fraction of a broth culture of Streptomyces herbaricolor HNS2-2.Trace analyses were performed and anti-microbial activities were determined. The antibiotic activity compounds were identified as quercetin dehydrate ①, p-hydroxyphenyl ②, 4’-hydroxyflavanone ③, and 3-hydroxyflavone ④ based on spectroscopic data. Compounds 1-4 showed significant antimicrobial activities against Staphylococcus aureus and the tobacco mosaic virus in vitro, suggesting their potential agricultural and medical applications.

Streptomyces Herbaricolor HNS2-2; Quercetin Dehydrate; p-Hydroxyphenyl; 4-Hydroxyflavanone; 3-Hydroxyflavone; Bioactivity

Chen, L. , Li, Y. , Zhu, H. , Liu, Y. and Gao, B. (2012) Fractionation and structural identification of antibiotic activity substances from Streptomyces herbaricolor HNS2-2. Agricultural Sciences, 3, 567-571. doi: 10.4236/as.2012.34068.