Author(s)

Rajendra N. Goyal, Sanghamitra Chatterjee, Sudhanshu P. Singh, Anoop Raj Singh Rana, Himanshu Chasta

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India.

A comparison of voltammetric behavior of bisoprolol fumarate (BF) at edge and basal plane pyrolytic graphite electrodes (EPPGE/BPPGE) has been made with single wall carbon nanotube modified glassy carbon. The electrochemical properties are investigated exercising the cyclic voltammetry and square wave voltammetry (SWV). Enhanced peak current associated with bisoprolol fumarate oxidation at EPPGE is due to its better electron transfer property. Quantification of bisoprolol fumarate was carried out at pH 7.2 at both the pyrolytic graphite electrodes. Well-defined peak has been observed at ~ 792 and 954 mV at EPPGE and BPPGE respectively for bisoprolol fumarate oxidation. The detection limit is found to be 2.8 × 10–7 M and 7.3 × 10–7 M for EPPGE and BPPGE respectively. A comparison of common quantification parameters for bisoprolol at carbon nanotube modified glassy carbon electrode and bare BPPGE and EPPGE has been made and it is observed that carbon naotube modified glassy carbon exhibits sensitivity and detection limit close to that observed at bare basal plane pyrolytic graphite electrode. The method developed is applicable for determination of bisoprolol fumarate in pharmaceutical preparations and real samples.

Voltammetry; Bisoprolol Fumarate; Carbon Nanotube; Edge/Basal Plane Pyrolytic Graphite; Pharmaceutical Samples; Human Urine

R. Goyal, S. Chatterjee, S. Singh, A. Rana and H. Chasta, "The Electrocatalytic Activity of Bare Pyrolytic Graphite and Single Wall Carbon Nanotube Modified Glassy Carbon Sensors Is Same for the Quantification of Bisoprolol Fumarate," American Journal of Analytical Chemistry, Vol. 3 No. 2, 2012, pp. 106-112. doi: 10.4236/ajac.2012.32015.