Pharmacology & Pharmacy

Volume 3, Issue 1 (January 2012)

ISSN Print: 2157-9423   ISSN Online: 2157-9431

Google-based Impact Factor: 0.70  Citations  h5-index & Ranking

Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review

HTML  XML Download Download as PDF (Size: 180KB)  PP. 62-71  
DOI: 10.4236/pp.2012.31010    6,615 Downloads   13,337 Views  Citations

Affiliation(s)

.

ABSTRACT

The kinases have been intensely studied because of their involvement in regulating essential cellular activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. Recent cancer genomic sequencing studies have revealed that many more kinases contribute to tumor genesis and are potential targets for inhibitor drug development intervention. Herein we review recent results that have helped to unravel the indolin-2-ones underlying the confiicting roles of the kinase inhibition regulation. This review focuses on the potential of kinases as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of indolin-2-ones as kinase inhibitors.

Share and Cite:

C. Prakash, P. Theivendren and S. Raja, "Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review," Pharmacology & Pharmacy, Vol. 3 No. 1, 2012, pp. 62-71. doi: 10.4236/pp.2012.31010.

Cited by

[1] Virtual Screening and Molecular Docking: Discovering Novel c-KIT Inhibitors
Current Medicinal …, 2022
[2] Transition metal-free functionalization of 2-oxindoles via sequential aldol and reductive aldol reactions using rongalite as a C1 reagent
Organic & Biomolecular …, 2022
[3] Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors
International journal of molecular …, 2022
[4] The Development of 3-substituted Indolin-2-one Derivatives as Kinase Inhibitors for Cancer Therapy
Current Medicinal Chemistry, 2022
[5] 3-Substituted-2-oxindole derivatives: Design, synthesis and their anti-tuberculosis and radical scavenging dual-action studies
Journal of Molecular …, 2022
[6] Molecular Docking and In Vitro Anticancer Screening of Synthesized Arylthiazole linked 2H-indol-2-one Derivatives as VEGFR-2 Kinase Inhibitors
Anti-Cancer Agents …, 2022
[7] Logical synthetic strategies and structure-activity relationship of indolin-2-one hybrids as small molecule anticancer agents: An overview
Journal of Molecular …, 2022
[8] Isatin-hydrazide conjugates as potent α-amylase and α-glucosidase inhibitors: Synthesis, structure and in vitro evaluations
Bioorganic …, 2021
[9] Synthesis of the Kinase Inhibitors Nintedanib, Hesperadin, and Their Analogues Using the Eschenmoser Coupling Reaction
The Journal of Organic …, 2021
[10] Recent Advances in N‐Heterocyclic Carbene Catalyzed Oxidative Cyclization for the Formation of Heterocycles
Asian Journal of Organic Chemistry, 2021
[11] Ultrasound‐assisted synthesis of 3‐(1‐(2‐(1H‐indol‐3‐yl)ethyl)‐2‐aryl‐6,6‐dimethyl‐4‐oxo‐4,5,6,7‐tetrahydro‐1H‐indol‐3‐yl)indolin‐2‐ones by novel core‐shell bio‐based nanocatalyst anchoring sulfonated L‐histidine on …
2020
[12] Anticancer compounds based on isatin-derivatives: strategies to ameliorate selectivity and efficiency
2020
[13] Recent Advances in the Utility of Glycerol as a Benign and Biodegradable Medium in Heterocyclic Synthesis
2019
[14] Eco‐friendly Polyethylene Glycol‐400 as a Rapid and Efficient Recyclable Reaction Medium for the Synthesis of Anticancer Isatin‐linked Chalcones and Their 3‐Hydroxy Precursor
Journal of heterocyclic chemistry, 2019
[15] Oxidative Assets Toward Biomolecules and Cytotoxicity of New Oxindolimine-Copper (II) and Zinc (II) Complexes
2019
[16] Novel 3-((2-chloroquinolin-3-yl) methylene) indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
2019
[17] Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams
2019
[18] DNA binding, cytotoxic effects and probable targets of an oxindolimine-vanadyl complex as an antitumor agent.
2019
[19] The effect of combined drug treatment on HL60 cells
2019
[20] Domino carbometalation/coupling reactions of N-arylpropiolamides: a novel and promising synthetic strategy toward stereocontrolled preparation of highly …
RSC Advances, 2017
[21] Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule
2017
[22] Oxalic Acid as Sustainable CO Source for Pyrrolone‐Fused Benzosuberenes Synthesis through Palladium Catalyzed Carbonylative Cyclization
ChemistrySelect, 2017
[23] Iodine-Catalyzed Regioselective Synthesis of Multisubstiuted Pyrrole Polyheterocycles Free from Rotamers and Keto–Enol Tautomers
The Journal of Organic Chemistry, 2017
[24] Heterocyclic Analogues as Kinase Inhibitors: A Focus Review
Current Topics in Medicinal Chemistry, 2017
[25] Domino carbometalation/coupling reactions of N-arylpropiolamides: a novel and promising synthetic strategy toward stereocontrolled preparation of highly …
RSC Advances, 2017
[26] Peptide–Drug Conjugate GnRH–Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth
2016
[27] Imobilização de complexos oxindolimínicos de cobre e zinco em argilas beidelitas
Thesis, 2016
[28] Peptide–Drug Conjugate GnRH–Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor GrowthA Potent Sunitinib–GnRH Conjugate for …
Cancer research, 2016
[29] Prevalence of bacterial and fungal diseases in dromedary camels in the Rajasthan state of India.
2015
[30] Design, synthesis and biological evaluation of bioconjugates for selective drug delivery and tumour targeting
2015
[31] Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation–Michael addition–cyclization sequence under catalyst-and solvent-free conditions
Green Chemistry, 2015
[32] Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation-Michael addition-cyclization sequence under catalyst-and solvent-free conditions
Green Chemistry, 2015
[33] Proxy-PET Building Blocks as a Design Element for Library Synthesis
Dissertation, Wright State University, 2015
[34] Design and Synthesis of 3-Substituted Indolin-2-one Derivatives with Methyl (E)-2-(3-Methoxy) acrylate Moiety
Asian Journal of Chemistry, 2015
[35] Synthesis of 3‐(γ, δ‐Disubstituted) allylidene‐2‐Oxindoles from Isatins by Wittig Reaction with Morita–Baylis–Hillman Bromides
Bulletin of the Korean Chemical Society, 2015
[36] A one-pot 'click'reaction from spiro-epoxides catalyzed by Cu (i)-pyrrolidinyl-oxazole-carboxamide
New Journal of Chemistry, 2015
[37] Design and Synthesis of 3-Substituted Indolin-2-one Derivatives with Methyl (E)-2-(3-Methoxy) acrylate Moiety.
Asian Journal of Chemistry, 2015
[38] QSAR and molecular docking studies on oxindole derivatives as VEGFR-2 tyrosine kinase inhibitors
Journal of Receptors and Signal Transduction, 2015
[39] Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes
JBIC Journal of Biological Inorganic Chemistry, 2015
[40] Microwave-Assisted, Multicomponent, Ecofriendly Synthesis of 3-Bihetaryl-2-Oxindole Derivatives Grafted with Phenothiazine Moiety
Synthetic Communications, 2015
[41] Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions
Tetrahedron Letters, 2015
[42] Highly Stereoselective [4+ 2] and [3+ 2] Spiroannulations of 2‐(2‐Oxoindolin‐3‐ylidene) acetic Esters Catalyzed by Bifunctional Thioureas
Chemistry–A European Journal, 2015
[43] Peptide-drug conjugate GnRH-sunitinib targets angiogenesis selectively at the site of action to inhibit tumor growth
Cancer research, 2015
[44] 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008–2014)
Expert opinion on therapeutic patents, 2015
[45] An expedient synthesis of 3-alkylideneoxindoles by Ti (O< sup> i Pr)< sub> 4/pyridine-mediated Knoevenagel condensat
Tetrahedron Letters, 2014
[46] The Indolinone MAZ51 Induces Cell Rounding and G2/M Cell Cycle Arrest in Glioma Cells without the Inhibition of VEGFR-3 Phosphorylation: Involvement of the RhoA and Akt/GSK3β Signaling Pathways
PloS one, 2014
[47] Vinylogous< i> N,< i> N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with< i> N,< i> N
Tetrahedron Letters, 2014
[48] Efficient synthesis of new oxindol-based heterocyclic entities via indolin-2-one derivatives
Arabian Journal of Chemistry, 2014
[49] Syntheses and Evaluation of Carbon-11-and Fluorine-18-Radiolabeled pan-Tropomyosin Receptor Kinase (Trk) Inhibitors: Exploration of the 4-Aza-2-oxindole Scaffold as Trk PET Imaging Agents
ACS chemical neuroscience, 2014
[50] Vinylogous N, N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with N, N-dimethylformamide dimethylacetal
Tetrahedron Letters, 2014
[51] The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the …
2014
[52] Syntheses and evaluation of carbon-11-and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as …
ACS Chemical Neuroscience, 2014
[53] An expedient synthesis of 3-alkylideneoxindoles by Ti (OiPr) 4/pyridine-mediated Knoevenagel condensation
Tetrahedron Letters, 2014
[54] The Indolinone MAZ51 Induces Cell Rounding and G2
2014
[55] Synthesis, Structure-Activity Relationships and Biological Activity of New Isatin Derivatives as Tyrosinase Inhibitors
Current topics in medicinal chemistry, 2014
[56] The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the …
PLOS ONE, 2014
[57] Cyclodextrin host as a supramolecular catalyst in nonpolar solvents: stereoselective synthesis of (E)-3-alkylideneoxindoles
Tetrahedron, 2013
[58] Cyclodextrin host as a supramolecular catalyst in nonpolar solvents: stereoselective synthesis of (< i> E)-3-alkylideneoxind
Tetrahedron, 2013
[59] Libraries from Libraries Approach to the Synthesis of Arylidene Oxindoles
2013
[60] Rational design of protein kinase inhibitors
Biopolymers and Cell, 2013
[61] The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
2012

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.