Author(s)

Amira Saoudi¹, Oumaima Siyouri², Samia Mhirech¹, Hajar Medyouni², Jihane Chouef², Soussy Kawtar¹, Lamiae Amaadour², Karima Oualla², Zineb Benbrahim², Wissal Hassani¹, Fatimazahra Farhane¹, Zenab Alami¹, Samia Arifi², Nawfel Mellas², Touria Bouhafa¹

¹Department of Radiotherapy, Chu Hassan II of Fes, Fes, Morocco.
²Hospital of Medical Oncology, Chu Hassan II of Fes, Fes, Morocco.

Background: The purpose of the present study was to investigate the clinicopathological characteristics and prognostic factors of second primary oral squamous cell carcinoma after radiotherapy for head and neck cancer. Methods: The clinicopathological characteristics of 27-second primary oral squamous cell carcinoma patients with a history of radiotherapy for head and neck cancer were retrospectively analyzed by Kaplan-Meier survival analysis and Cox proportional hazards model, including gender, age, alcohol consumption, smoking, clinical stage, margin status, regional lymph node status, tumor differentiation and treatment mode. Results: The second primary oral squamous cell carcinoma mostly occurred on the tongue (11/27), buccal (9/27) and gingiva (7/27), and the 3- and 5-year overall survival (OS) was 60.3% and 39.4%, respectively. Margin status and extranodal extension were significantly associated with OS, while only margin status was found to be an independent prognostic factor of OS in the Cox proportional hazards model (P = 0.003, HR = 3.976, 95% CI: 1.596 - 9.904). Conclusion: Oral squamous cell carcinoma patients who underwent radiotherapy for head and neck cancer show poor survival outcomes. Margin status is an independent prognostic factor of second primary oral squamous cell carcinoma.

Second Primary, Malignancy, Squamous Cell Carcinoma, Oral Cavity, Radiation

Saoudi, A. , Siyouri, O. , Mhirech, S. , Medyouni, H. , Chouef, J. , Kawtar, S. , Amaadour, L. , Oualla, K. , Benbrahim, Z. , Hassani, W. , Farhane, F. , Alami, Z. , Arifi, S. , Mellas, N. and Bouhafa, T. (2024) Second Primary Oral Squamous Cell Carcinoma after Radiotherapy: A Retrospective Study, over 5 Years, about 27 Cases. Open Access Library Journal, 11, 1-8. doi: 10.4236/oalib.1111462.