Guillain-Barré Syndrome Following AstraZeneca COVID-19-Vaccination: Two Cases Report Study ()
Author(s)
Soukaina Benlamkadam1,2,
Yahya Naji3,4,
Yasmina Zakaria1,2,
Nissrine Louhab1,2,
Mohamed Chraa1,2,
Najib Kissani1,2
Affiliation(s)
1Department of Neurology, University Hospital Mohamed VI, Marrakech, Morocco.
2Neuroscience Research Laboratory, Marrakesh Medical School, Marrakech, Morocco.
3Department of Neurology, University Hospital of Agadir, Agadir, Morocco.
4“N.I.C.E.” Team Research, “R.E.G.N.E.” Research Laboratory, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, Agadir, Morocco.
ABSTRACT
Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy. It is recognized as a serious condition, because it includes dysautonomia and respiratory affection. In fact, there have been an increasing number of reports about GBS vaccine-related vaccinations as the COVID-19 vaccination campaign goes on. Here, we report two cases of Guillain-Barré syndrome (GBS) following the first dose of the Oxford/AstraZeneca COVID-19 vaccine. Symptoms appeared 21 days after vaccination, with acute progressive bilateral symmetric ascending flaccid tetra-paresis. The electromyography was compatible with a motor demyelinating polyneuropathy, confirming the diagnosis of the Guillain-Barré syndrome. Management with intravenous immunoglobulin was prescribed, with favorable outcomes. Clinical and laboratory tests confirmed the Guillain-Barré syndrome and the period from the date of vaccination to the appearance of initial symptoms, added to the absence of other causes, allowed to assume that the vaccination could be the cause. The literature is still unable to determine the pathogenesis of GBS due to COVID-19 vaccination. However, the findings underscore the importance of continuous surveillance and investigation into potential adverse effects of COVID-19 vaccines, emphasizing the need for informed decision-making and vigilant monitoring in vaccination campaigns.
Share and Cite:
Benlamkadam, S. , Naji, Y. , Zakaria, Y. , Louhab, N. , Chraa, M. and Kissani, N. (2024) Guillain-Barré Syndrome Following AstraZeneca COVID-19-Vaccination: Two Cases Report Study.
Open Access Library Journal,
11, 1-7. doi:
10.4236/oalib.1111356.
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