Author(s)

Ghita Bourkadi¹, Sanae Habibi¹, Sana Abourazzak^2,3, Moustapha Hida^2,3

¹Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, Morocco.
²Department of Pediatrics, Hassan II University Hospital, Fez, Morocco.
³Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocoo.

Background: Hypothalamic hamartoma is a rare non-neoplastic lesion, typically identified in early childhood during investigations for precocious puberty and/or gelastic seizures. However, cases of diagnosis even earlier or during fetal development have been documented. Case Presentation: A newborn girl was diagnosed with hydrocephalus during pregnancy. An MRI revealed a large oval hypothalamic process, which suggested a hypothalamic hamartoma. At the age of 2, she experienced alternating crying and laughing seizures, followed by a decrease in visual acuity. Due to involvement of the optic pathways, surgery was not performed and she underwent antiepileptic medicines and gamma knife radiotherapy. At the age of 5 years and 3 months, she presented with breast development and laboratory tests confirmed central precocious puberty. Quarterly injections of GnRH agonists have since been administered with favorable results. Conclusion: Early-diagnosed hypothalamic hamartomas require close monitoring, by an experienced multidisciplinary, to promptly detect and treat potential complications, especially precocious puberty, and prevent any undesirable impact on final height.

Perinatally-Hypothalamic Hamartoma-Giant-Precocious Puberty

Bourkadi, G. , Habibi, S. , Abourazzak, S. and Hida, M. (2024) Precocious Puberty in a 5-Year-Old Girl with a Giant Hypothalamic Hamartoma Discovered Perinatally: Case Report. Open Journal of Endocrine and Metabolic Diseases, 14, 101-106. doi: 10.4236/ojemd.2024.144012.