Author(s)

Larisa Mikhailovna Obukhova¹, Elena Ivanovna Erlykina², Igor Aleksandrovich Medyanik¹, Artem Sergeevich Grishin¹, Angelina Mikhailovna Shutova¹

¹Federal State Budgetary Educational Institution of Higher Education, The “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
²National Research Lobachevsky State, University of Nizhny Novgorod, Nizhny Novgorod, Russia.

Metabolic reprogramming is a key feature driving oncogenesis in cancers. Recent studies have revealed that protein metabolism is largely altered in gliomas facilitating its malignant growth. Urea is the end product of nitrogen metabolism which is mainly produced by arginase. The interdependence of arginase and other biochemical mechanisms triggered scientific research interest. This research aimed to investigate the relationships between the urea as the main parameter of protein metabolism and glioma progression. It was also the most pronounced relationship between urea and the level of the nuclear protein Ki-67 as a marker of proliferative activity and O-6-methylguanine-DNA methyltransferase (MGMT), which performs DNA repair. Postoperative material from 20 patients with gliomas of different grades of anaplasia was analyzed.

Glioma, Peritumoral Zone, Urea, Gliomal Molecular Genetic Markers, Ki-67, MGMT

Obukhova, L. , Erlykina, E. , Medyanik, I. , Grishin, A. and Shutova, A. (2024) Brain Urea as a Potential Biomarker of Neoplasm Progression. Journal of Biosciences and Medicines, 12, 1-13. doi: 10.4236/jbm.2024.124001.