Author(s)

Sanra Déborah Sanogo^1*, Kadiatou Doumbia², Hourouma Sow², Moussa Younoussou Dicko², Youssouf Oumarou³, Abdoulaye Berthé², Sabine Drabo¹, Luc Sidibé¹, Makan Siré Tounkara², Abdoulaye Maiga¹, Ouatou Mallé¹, Ganda Soumaré¹, Anselme Konaté², Moussa Tièmoko Diarra²

¹Hepato-Gastroenterology Department, CHU Point G, Bamako, Mali.
²Hepato-Gastroenterology Department, CHU Gabriel Touré, Bamako, Mali.
³Department of Internal Medicine, Centre Hospitalier Universitaire Communautaire de Bangui, Bangui, Central African Republic.

Infection with the defective hepatitis D virus (HDV) co-infects or superinfects a patient carrying hepatitis B virus (HBV). Delta virus infection is relatively common. The seriousness of infection with the hepatitis D virus (HDV), a virus defective in a patient carrying the hepatitis B virus (HBV), lies in its aggravating effect on the associated viral hepatitis B. Our aim was to study the serological profile of HDV in HBsAg-positive patients. As this study was fragmentary, we initiated this study with the aim of investigating the serological profile of HDV in HBsAg-positive patients. This was a descriptive and analytical cross-sectional study that ran from March 2019 to February 2020, a 12-month period. It focused on the population of patients seen and screened positive for HBsAg. We obtained a frequency of 10%. The mean age of our patients was 41.8 ± 13.09 years. The sex ratio was 4.5. VHD RNA was detected in 50% of patients. In 100% of cases, the presence of VHD RNA was associated with advanced fibrosis according to the APRI score, but without any statistically significant link. All HBV-infected patients should be screened for anti-HDV Ac. HDV infection leads to rapid progression to complications of liver disease.

HBsAg, VHD RNA, Liver Disease

Sanogo, S. , Doumbia, K. , Sow, H. , Dicko, M. , Oumarou, Y. , Berthé, A. , Drabo, S. , Sidibé, L. , Tounkara, M. , Maiga, A. , Mallé, O. , Soumaré, G. , Konaté, A. and Diarra, M. (2024) Serological Profile of Hepatitis D Virus (Hepatitis Delta) in the Hepato-Gastro-Enterology Department of Chu Gabriel Toure. Open Journal of Gastroenterology, 14, 93-98. doi: 10.4236/ojgas.2024.143010.