Author(s)

Mariama Sadjo Diallo^1,2,3*#, Doufin Traore^1,2#, Adame Diouf⁴, Djiba Kaba^1,2, Issiaga Diallo^1,2, Doudou Georges Massar Niang⁴, Alimou Camara¹, Oumar Mouctar Diallo^1,2, Boh Fanta Diane^1,5, Abdoulaye Barry^1,6, Ouo-Ouo Yaramon Kolie², Moustapha Mbow⁴, Aly Badra Kamissoko^1,6, Djibril Sylla^1,7, Babacar Mbengue⁴, Mohamed Cisse^1,5

¹Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Conakry, Guinée.
²Laboratoire de Biologie Moléculaire Nestor BANGOURA/Helene LABROUSSE, Hôpital de jour Donka, CHU Donka, Conakry, Guinée.
³Centre d’Excellence Africain Pour la Prévention et le Contrôle des Maladies Transmissibles, Conakry, Guinée.
⁴Laboratoire d’Immunologie, Université Cheikh Anta Diop, Dakar, Sénégal.
⁵Service de Dermatologie-Vénérologie, CHU Donka, Conakry, Guinée.
⁶Service de Rhumatologie, Hôpital National Ignace Deen, Conakry, Guinée.
⁷Service de Médecine Interne, CHU Donka, Conakry, Guinée.

Connective tissue diseases (CTDs) are Autoimmune diseases (AIDs) characterized by the appearance of autoantibodies, which are diagnostic markers. Investigations of these autoantibodies play a major role in the management of several autoimmune diseases. The objective of this study was to describe the profile of anti-ENA antibodies according to the clinical symptoms of mixed CTDs in Conakry teaching Hospital. We performed a cross-sectional study during six months. A total of 20 patients was recruited and we measured antibodies using the ELISA technique. The mean age of our patients was 36.5 years, with a predominance of females. Cutaneous and rheumatological signs were the main clinical manifestations. SLP was the most frequent CTDs; the threshold of ENA antibodies positivity was higher in scleroderma with and SLP. Anti-ENA identification reveals the frequency of anti-SSA (83.33%), anti-U1RNP (66.66%) and anti-histone (50%) antibodies. Antinuclear antibodies (ANA) react with various components of the cell nucleus. Their detection is of major interest in the diagnosis of CTDs. Our results highlight the importance of determining the specificity of these antibodies to guide differential diagnosis.

Autoantibodies, Extractible Nuclear Antigen (ENA), Connective Tissue Diseases, ELISA

Diallo, M. , Traore, D. , Diouf, A. , Kaba, D. , Diallo, I. , Niang, D. , Camara, A. , Diallo, O. , Diane, B. , Barry, A. , Kolie, O. , Mbow, M. , Kamissoko, A. , Sylla, D. , Mbengue, B. and Cisse, M. (2024) Profile of Autoantibodies and Clinical Symptoms in Guinean Patients with Connective Tissue Diseases. Open Journal of Immunology, 14, 1-10. doi: 10.4236/oji.2024.141001.