Author(s)

Tkhu Chang Le^1,2,3, Qian Zhang^1,2, Qingdi Qu^1,2, Wentong Ding^1,2, Sergej Anatolyevich Lazarev³, Shuang Pan^1,2*

¹The First Affiliated Hospital of Harbin Medical University, Harbin, China.
²Department of Endodontics, School of Stomatology, Harbin Medical University, Harbin, China.
³Department of Prosthodontics, Bashkir State Medical University, Ufa, Russia.

Regenerative medicine progress is based on the development of cell and tissue bioengineering. One of the aims of tissue engineering is the development of scaffolds, which should substitute the functions of the replaced organ after their implantation into the body. The tissue engineering material must meet a range of requirements, including biocompatibility, mechanical strength, and elasticity. Furthermore, the materials have to be attractive for cell growth: stimulate cell adhesion, migration, proliferation and differentiation. One of the natural biomaterials is silk and its component (silk fibroin). An increasing number of scientists in the world are studying silk and silk fibroin. The purpose of this review article is to provide information about the properties of natural silk (silk fibroin), as well as its manufacture and clinical application of each configuration of silk fibroin in medicine. Materials and research methods. Actual publications of foreign authors on resources PubMed, Medline, E-library have been analyzed. The selection criteria were materials containing information about the structure and components of silk, methods of its production in nature. This article placed strong emphasis on silk fibroin, the ways of artificial modification of it for use in various sphere of medicine.

Tissue Engineering, Biomaterial, Scaffold, Silk, Fibroin

Le, T. , Zhang, Q. , Qu, Q. , Ding, W. , Lazarev, S. and Pan, S. (2024) A Review on Silk Fibroin as a Biomaterial in Tissue Engineering. Journal of Biosciences and Medicines, 12, 275-290. doi: 10.4236/jbm.2024.123023.