Author(s)

Fathima Assainar¹, Joshua George Thomas^2*, Zoya Saleem², Shafa Thekkekara¹, Fathima Mammoo¹, Navadir Nidal Kallan³

¹RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE.
²Department of Biotechnology, American University of Ras Al Khaimah, Ras Al Khaimah, UAE.
³School of International Education, Zhengzhou University, Zhengzhou, China.

The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provides an overview of exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic effect is that the phospholipid-binding protein ANXA1 improves its anti-inflammatory properties. The review also analyzes the intricate processes of exosome production and composition ability to transport biomolecules such as proteins, microRNAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of targeted drug administration due to their innate specificity. Through genetic engineering and chemical modifications, exosomes can be tailored for specific purposes, demonstrating their versatility in targeted therapy. With ongoing research uncovering their therapeutic potential, exosomes present a promising frontier in novel medical treatments across various health conditions.

Exosomes, Cancer, Coeliac Disease, Therapeutic Potential, Cell Communication, Anti-inflammation

Assainar, F. , Thomas, J. , Saleem, Z. , Thekkekara, S. , Mammoo, F. and Kallan, N. (2024) A Comprehensive Review of Exosomes with Therapeutic Potential in Cancer and Coeliac Disease. Journal of Biosciences and Medicines, 12, 25-34. doi: 10.4236/jbm.2024.123003.