Effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients ()
ABSTRACT
Objective: To determine the effect of
flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients. Methods: In this double-blind randomized controlled study, patients aged 65 to 80
who were undergoing spinal fusion surgery for disc herniation were administered
flurbiprofen 100 mg (P group, flurbiprofen group),
prednisolone 0.6 mg/kg (D group, prednisolone group), prednisolone 0.6 mg/kg plus flurbiprofen 100 mg
(P + D group, flurbiprofen + prednisolone group) or normal
saline (S group, saline group) 15 minutes before the
induction of anesthesia. Plasma samples were collected before surgery (T0) and on day 1 (T1), day 2
(T2) and day 3 (T3) following surgery. At the same time, systemic
inflammatory response syndrome (SIRS) was assessed by SIRS criteria. The levels
of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)
and C-reactive protein (CRP) for collected samples were measured. Results: Other
groups had significantly lower levels of IL-6, CRP and occurrence of SIRS than
S group (p < 0.05). Compared to groups P and D, the levels of IL-6
and CRP in P + D group were significantly lower on T1 (p < 0.05). Peak levels of IL-6 in all groups were presented
on T1 (p < 0.05). The levels of CRP within three days were
significantly different but did not show
peak levels (p > 0.05). Conclusion: Compared to prednisolone or flurbiprofen, combining flurbiprofen with
prednisolone in elderly surgery patients led to an increased suppression of
IL-6.
Share and Cite:
Lin, J. , Yang, H. , Chen, S. and Xu, J. (2024) Effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients.
Pharmacology & Pharmacy,
15, 15-26. doi:
10.4236/pp.2024.152002.
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