Male and Female Hypogonadisms: Etiological, Metabolic and Osteodensitometric Aspects ()
Affiliation(s)
1Department of Metabolic and Endocrine Diseases, Brazzaville University Hospital, Brazzaville, Republic of the Congo.
2Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo.
3Department of Endocrinology, Metabolic Diseases, Hassan II University Hospital of Fez, Fez, Morocco.
ABSTRACT
Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia,
type 2 diabetes in cases of low testosterone in men and which are associated with
increased cardiovascular risk. Hypogonadism
represents the second cause of endocrine osteoporosis. Objectives: The objectives
of our work were: to determine the main causes of hypogonadism in women and men;
to assess the frequency of metabolic and osteosdensitometric abnormalities in the
hypogonadal population. Patients and methods: A retrospective descriptive
study was carried out over 7 years on 120 patients, hospitalized in the Endocrinology
department of the Hassan II University Hospital of Fez-Morocco for hypogonadism.
The patients selected were those who had symptoms of hypogonadism confirmed in men
by: low total testosterone for Tanner stage in adolescents, <3 ng/ml or
lower limit of normal for adults; in women, hypoestrogenia < 30 pg/l. Gonadotropin
dosage, karyotype, pelvic or testicular ultrasound and pituitary MRI, for etiological
diagnosis, were performed. Bone densitometry was performed for bone impact and lipid
profile for metabolic profile. Results: Out of 120 patients, there were 77 women and 43 men.
The average age was 31.51 years. In men, the main causes were central hypogonadism
in 67.4% and primary testicular failure in 32.6%. In women, central hypogonadism
was also the most common cause noted in 63.7% and premature ovarian failure was
observed in 36.4%. HypoHDL was significantly more frequent p (0.005) in women, osteopenia and
osteoporosis were significantly more frequent in women than in men p (0.046). Conclusion: Central causes represent the most common etiology of
hypogonadism in both sexes; abnormalities of bone mineralization and metabolic disorders
were predominant in women.
Share and Cite:
Mbamognoua, N. , Damoune, I. , Doubi, S. , Lahlou, A. and Ajdi, F. (2024) Male and Female Hypogonadisms: Etiological, Metabolic and Osteodensitometric Aspects.
Open Journal of Endocrine and Metabolic Diseases,
14, 39-52. doi:
10.4236/ojemd.2024.142006.
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