Author(s)

Godspower Oghenemaroh Sebe¹, Supreme O. Oghenerhoro², Ogbole E. Jonathan¹, Ebuka Victor Anyaogu³, Adeyemo David Adebowale³, Raymond Chidozie Ntomchukwu⁴

¹Department of Chemical, Chemistry and Biomedical Engineering, University of New Haven, West Haven, USA.
²Chemistry and Biochemistry, University of Toledo, Toledo, USA.
³Department of Cell and Molecular Biology, University of New Haven, West Haven, USA.
⁴Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria.

This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat.

Pseudomonas aeruginosa PAO1, Antibiotic Resistance, Next-Generation Antibiotics, Adjuvant Synergy, Intracellular Accumulation, Penetration Rates, Minimum Inhibitory Concentration (MIC), Resistance Tra-jectory, Fluorescence Quantification

Oghenemaroh Sebe, G. , O. Oghenerhoro, S. , E. Jonathan, O. , Victor Anyaogu, E. , David Adebowale, A. and Chidozie Ntomchukwu, R. (2023) Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in Pseudomonas aeruginosa PAO1. Journal of Biomedical Science and Engineering, 16, 107-120. doi: 10.4236/jbise.2023.168008.