Author(s)

Koffi Konan Martin¹, Sadia Sahi Placide¹, Kouadio Brou Albert², Gnamba Corneil Quand-Même³, Fofié Thiery Auguste Appia³, Koffi Konan Sylvestre³, Lassiné Ouattara³

¹UFR Environnement, Université Jean Lorougnon Guédé, Daloa, Côte d’Ivoire.
²UFR Sciences et Technologies, Université Alassane Ouattara, Bouaké, Côte d’Ivoire.
³Laboratoire de constitution et de réaction de la matière, UFR SSMT, Université Félix Houphouet Boiguy, Abidjan, Côte d’Ivoire.

This article describes the use of a boron-doped diamond electrode (BDDE) as an electrochemical sensor for the simultaneous determination of omnipaque (OMP) and paracetamol (PCM) in perchloric acid medium (HClO4 0.1 M) and in complex matrices such as tomato, carrot and cucumber juices and waste water from the Treichville University Hospital. Voltammetric studies allowed us to have well-defined oxidation peaks at distinct potentials of OMP (E = 0.5 V/SCE) and PCM (E = 0.7 V/SCE). Under optimized conditions, well-defined quantities of OMP and PCM, introduced simultaneously by metered additions, gave linear responses in concentration ranges of 259.8 - 467.2 μM for OMP and 58.73 - 116.3 μM PCM. The detection limits obtained are 7.23 μΜ and 3.6 μΜ respectively for OMP and PCM with recovery rates between 85.8% ± 0.1% and 92.6% ± 0.1% for OMP and between 99.9% ± 0.1% and 101.2% ± 0.4% for the PCM. This technique has been successfully used to simultaneously detect these pharmaceuticals in these complex environments. It allows recovery of OMP and PCM respectively up to 97.5% ± 0.0% and 91.6% ± 0.3% in tomato juice; 100.0% ± 0.0% and 95.2% ± 0.2% in carrot juice; 101.4% ± 0.1% and 97.3% ± 0.3% in cucumber juice; 100.1% ± 0.9% and 100.9% ± 0.1% in wastewater. The relevance of this technique for the simultaneous detection of OMP and PCM in tomato, carrot, cucumber juices and in waste water can be studied in the context of the contamination of certain fruits and vegetables by the substances organic pharmaceuticals released into the environment without prior treatment.

Omnipaque, Paracétamol, Differential Pulse Voltammetry, Boron Doped Diamond Electrode

Martin, K. , Placide, S. , Albert, K. , Quand-Même, G. , Appia, F. , Sylvestre, K. and Ouattara, L. (2023) Differential Pulse Voltammetric Simultaneous Determination of Paracetamol and Omnipaque on Boron Doped Diamond Electrode: Application to Natural Tomato, Carrot, Cucumber Juices and Wastewater. American Journal of Analytical Chemistry, 14, 434-450. doi: 10.4236/ajac.2023.1410025.