Author(s)

Pedro Hinojosa-Gómez^1,2, Sergio Fausto-Guerra³, Guillermo Nolasco-Rodríguez¹, Lucia García-Delgado¹, Víctor Barragán-Cano¹, Manuel Rosales-Cortés¹, Esther Albarrán-Rodríguez¹, José Ricardo Cuéllar-Pérez^1*

¹Department of Veterinary Medicine, University Center for Agricultural Biological Sciences, University of Guadalajara, Jalisco, Mexico.
²Doctorate of Sciences in Ecophysiology and Genetic Resources, University Center for Agricultural Biological Sciences, University of Guadalajara, Jalisco, Mexico.
³Department of Botany and Zoology, University Center for Agricultural Biological Sciences, University of Guadalajara, Jalisco, Mexico.

Objective: The present study consisted of challenging the extract of kombucha and the fungus Ganoderma reported as hypoglycemic and used as alternative treatments against diabetes on the number and morphology of islets of Langerhans. Material and Methods: 64 Wistar rats were used in 4 groups: one control, three experimental, streptozotocin, Kombucha y Ganoderma induced diabetes with streptozotocin. Divided into four post-induction stages at 2, 15, 30 and 45 days of treatment, sacrificing 4 rats at each stage, to perform the morphological analysis of the pancreas. Results: A decrease in the islets of Langerhans in size, volume and the number of cells within them was identified for the streptozotocin group from the second stage until almost disappearing due to diabetes, in the groups of Kombucha y Ganoderma the same was observed but they were recovered with the extract treatments and the average number of islets was similar in these groups, the group of Ganoderma. Conclusion: Under the conditions of this work, a protective and regenerative effect of both extracts is identified.

Rats, Diabetes, Streptozotocin, Ganoderma, Kombucha, Pancreas

Hinojosa-Gómez, P. , Fausto-Guerra, S. , Nolasco-Rodríguez, G. , García-Delgado, L. , Barragán-Cano, V. , Rosales-Cortés, M. , Albarrán-Rodríguez, E. and Cuéllar-Pérez, J. (2023) Protective and Regenerative Effect of the Extract of Kombucha and the Fungus Ganoderma sichuanense on the Islets of Langerhans of Diabetic Rats. Open Journal of Veterinary Medicine, 13, 173-185. doi: 10.4236/ojvm.2023.1310015.