Author(s)

Emeline Sorelle Mefouegang¹, Claudelle Sybilline Anensong Djadock¹, Golngar Djimassingar^1,2, Gabriel Tchuente Kamsu³, Donald Raoul Tchuifon Tchuifon^1,4*, Alain Charly Tagne Kuate^1,5, Dirk Bockfeld⁵, Jean Ngoune^1*

¹Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
²Department of Fundamental Sciences, Mongo Polytechnique University Institute (IUPM), Mongo, Chad.
³Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
⁴Department of Process Engineering, Laboratory of Energy, Materials, Modeling and Method, National Higher Polytechnic School of Douala, University of Douala, Douala, Cameroon.
⁵Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany.

New cobalt(II) complex, [Co(O₂C₁₅H₁₁N₂S)₂(OH₂)₂]∙2H₂O (1∙2H₂O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)₂∙6H₂O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H₂O. Compound 1∙2H₂O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H₂O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H₂O displayed moderate activity (10 < MIC ≤ 100 μg/mL) on all Salmonellaand and, F1, and 018 yeasts. HL and 1∙2H₂O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).

Cobalt, Acylpyrazolone, X-Ray Diffraction, Antimicrobial Activity, 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

Mefouegang, E. , Djadock, C. , Djimassingar, G. , Kamsu, G. , Tchuifon, D. , Kuate, A. , Bockfeld, D. and Ngoune, J. (2023) Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One. Journal of Materials Science and Chemical Engineering, 11, 109-126. doi: 10.4236/msce.2023.118007.