Author(s)

Pablo Sisiruca¹, Gustavo Adolfo Socorro Calderas²

¹Saint James School of Medicine, Arnos Vale, Saint Vincent and the Grenadines.
²Jose Maria Vargas Medical School, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela.

Introduction: Thyroid states can be associated with psychiatric manifestations, be it hypothyroid, hyperthyroid or even euthyroid. The effect of depression is significant in subclinical hypothyroidism. Sometimes, its signs and symptoms are indistinguishable from Major Depressive Disorder. Our immunological system and early embryologic origins also play a role in the coexistence of other comorbidities like Pernicious Anemia. Case: A 35-year-old Hispanic female presented with significant low mood, somnolence, weight gain, increased hunger, cold intolerance and epigastric pain. It is important to note the variety of clinical manifestations of our hypothyroidism patient to understand its associations and help us with a better approach to treatment. Discussion: Standard approaches to treatment of Subclinical Hypothyroidism will depend mostly on laboratory findings such as TSH levels and free T4. Individualized therapy chosen for our patient was based on his mood symptoms, laboratory findings and coexistence of Pernicious Anemia. The use of daily 0.025 mg of levothyroxine, 10 mg of escitalopram oxalate and weekly injections of cyanocobalamin were treatments of choice. Conclusion: During follow up of our patient, we can conclude that Levothyroxine and Escitalopram Oxalate were able to improve hypothyroidism symptoms, reduce thyroglobulin and peroxidase antibodies and improve mood symptoms including cognitive functions. In addition to this, weekly cyanocobalamin injections were integrated into the management. As parietal cell antibodies decreased, gastrointestinal symptoms also disappeared. By addressing the concerns of our patient, we improved quality of care, and this is reflected in the patient’s wellbeing in physical and psychological.

Cyanocobalamin, Escitalopram Oxalate, Hashimoto’s Thyroiditis, Levothyroxine, Pernicious Anemia, Polyglandular Syndrome

Sisiruca, P. and Calderas, G. (2023) Subclinical Hypothyroidism, Its Manifestations and Management a Case Report. Open Journal of Internal Medicine, 13, 173-180. doi: 10.4236/ojim.2023.133020.