The Brain-Gut Axis in Alzheimer’s Disease ()
ABSTRACT
There is a vast colony of microbes in the human gut that not only maintains intestinal function but also has intricate links to the brain via the “microbiota-gut-brain” (MGB) axis. The axis now has been demonstrated to have implications for the treatment of several neuro-psychological illnesses, including Alzheimer’s Disease (AD), a condition that affects a person’s ability to connect socially and communicate effectively. Previously thought to be a rare disorder, it is now thought to affect 1 in 9 individuals in the United States. Unfortunately, there is not FDA-approved drug for the primary symptoms of AD, and the current cognitive-behavioral therapy procedures for the condition are time-consuming and expensive. Scientists are currently investigating the MGB axis to identify potential treatment targets to reduce AD symptoms. This review aims to highlight the functioning of the MGB axis; research into this dysfunction may effectively demonstrate the need of innovative AD treatment approaches, ranging from probiotics and dietary changes to more contemporary techniques like fecal transplants, vagal nerve stimulation, and gene therapy. Not simply behavioral intervention therapy, but also microbes, may hold the key to curing AD.
Share and Cite:
Patel, M. (2023) The Brain-Gut Axis in Alzheimer’s Disease.
Advances in Alzheimer's Disease,
12, 29-37. doi:
10.4236/aad.2023.123003.
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