Author(s)

Xianwang Wang^1*#, Xiao Zhang^1*, Shujuan Hu^2*, Lei Ge³, Zhiming Zou³, Yingying Lu^4#

¹Department of Biochemistry and Molecular Biology, Health Science Center, Yangtze University, Jingzhou, China.
²Institute of Education and Sports Sciences, Yangtze University, Jingzhou, China.
³Department of Ophtalmology, The Second School of Clinical Medicine & Jingzhou Central Hospital, Yangtze University, Jingzhou, China.
⁴The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Background: Uveal melanoma (UVM) is the most common primary intraocular tumor in adults. However, identification of the effective biomarker for the diagnosis and treatment of UVM remains to be explored. Calcium and integrin-binding protein 1 (CIB1) is emerging as an important factor in tumor progression. Purpose: To determine the contribution of CIB1 in the diagnosis of UVM. Method: Immunohistochemical staining is used to detect the CIB1 expression level, while Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and UALCAN online tools were used to analyze patient survival and CIB1 correlation genes in UVM. Integrative analysis using STRING and GeneMANIA predicted the correlated genes with CIB1 in UVM. Results: CIB1 expression level in UVM was significantly enhanced when compared with that in paracancerous tissues. A higher CIB1 expression level resulted in a significantly worse disease-free survival as well as overall survival. Moreover, the survival probability of patients was associated with body weight and gender of the patients with UVM. The correlated genes with CIB1 in UVM, and the similarity of the genes in UVM expression and survival heatmap were verified. Furthermore, Gene ontology enrichment analysis revealed that CIB1 and its correlated genes are significantly enriched in ITGA2B-ITGB3-CIB1 complex, regulation of intracellular protein transport and regulation of ion transport. Conclusions: Our novel findings suggested that CIB1 might be a potential diagnostic predictor for UVM, and might contribute to the potential strategy for UVM treatment by targeting CIB1

CIB1, Uveal Melanoma, TCGA, Prognostic Biomarker, Patient Survival

Wang, X. , Zhang, X. , Hu, S. , Ge, L. , Zou, Z. and Lu, Y. (2023) CIB1 as a Potential Diagnosis and Prognosis Biomarker in Uveal Melanoma. Yangtze Medicine, 7, 116-133. doi: 10.4236/ym.2023.72012.