Author(s)

Yuwei Wang, Lili Huo, Zeyi Huang, Xiaohui Shen, Chenxue Jin, Changqing Yang^*

Department of Digestive Internal Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.

Tumours of the digestive system include a number of malignant tumours such as oesophageal, gastric and colorectal cancers, which have the highest incidence and mortality rates in the world. Their occurrence is related to a variety of factors, such as diet, environment and genetics. As a key enzyme in the process of folate metabolism, MTHFR gene polymorphism plays an important role in the pathogenesis and development of gastrointestinal tumours. This paper provides a brief review of the relationship between MTHFR polymorphisms and digestive tumours, with a view to identifying the genetic effects of MTHFR, exploring the pathogenesis of digestive tract tumours and developing more effective prevention and treatment strategies.

MTHFR, Polymorphism, Esophageal Cancer, Gastric Cancer, Colorectal Cancer

Wang, Y. , Huo, L. , Huang, Z. , Shen, X. , Jin, C. and Yang, C. (2023) Research Progress on MTHFR C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors. Journal of Biosciences and Medicines, 11, 148-160. doi: 10.4236/jbm.2023.116012.