Author(s)

Toky Rakotoarivo^1*, Vonjy Andrianarison², Ny Ony Andrianandrasana³, Malala Razakanaivo², Florine Rafaramino²

¹Department of Oncology, University Hospital Tanambao, Antsiranana, Madagascar.
²Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.
³Department of Oncology, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.

Chemotherapy with 5-fluorouracil (5 FU) has been widely used to treat advanced gastric cancer. Knowing the side effects is therefore important in order to better prevent them. Fluoropyrimidine-induced hyperammonemic encephalopathy is a rare complication and characterized neurological status with elevated ammonia level without radiological abnormalities. We report the first case of 5 FU-induced hyperammonemic encephalopathy in women patients on induction chemotherapy for gastric cancer in Madagascar. His ammonia level (NH₃) was 102 μmol/l. The patient recovered from his confusional state after two days of treatment with hyperhydration and vitamin therapy.

Encephalopathy, Gastric Cancer, Hyperammonemia, 5-Fluororuracil

Rakotoarivo, T. , Andrianarison, V. , Andrianandrasana, N. , Razakanaivo, M. and Rafaramino, F. (2023) 5-Fluorouracil-Induced Hyperammonemia Encephalopathy in a Patient with Gastric Cancer. Journal of Cancer Therapy, 14, 102-106. doi: 10.4236/jct.2023.142009.