Author(s)

Maria Papavasileiou¹, Dionysios Aravantinos², Georgios Moustakas³, Alexandra Karamanou³, Stylianos Patsianis², Andreas Pittaras¹

¹Hypertension Clinic, Metropolitan General, Athens, Greece.
²Hygeia Hospital, Athens, Greece.
³Private Cardiologists, Athens, Greece.

Aim: The purpose of this study was to investigate the possible relationship of serum uric acid levels (SUA), in hypertensive patients treated or not, with blood clotting factors. Design and Methods: The study population consisted of 1297 hypertensive patients (46% men) treated (53%) or newly diagnosed untreated (mean age 57.8 years, mean office systolic/diastolic blood pressure -Ms/DBPo-: 147.9/91.6 mmHg, mean office heart rate -mHRo-: 75 ± 11.1 beats per minute, mean body mass index-Mbmi-: 28.2 ± 4.9 kg/m2, mean waist/hip ratio -Mw/H-: 0.88 ± 0.84 In the aforementioned patients SUA and blood clotting factors were measured, such as fibrinogen, international normalized ratio (INR) and serum homocysteine (Hcys). Moreover in a subgroup (N = 323) of the above mentioned study population, 323 patients, blood antithrombin III (ATIII), and D-dimers were also measured. Finally, in a small subgroup (N = 42) of the above mentioned study population of 42 patients, blood plasminogen activator inhibitor-1 (PAI-1) was measured. Values obtained were interrelated with Pearson correlation. Results: The following significant correlations were observed: SUA vs fibrinogen (r = 0.164; p < 0.001), SUA vs INR (r = 0.061, p = 0.029), SUA vs Hcys (r = 0.257, p < 0.001), SUA vs AT III (r = ?0.163, p = 0.021), SUA vs D-dimers (r = 0.120, p = 0.046 and SUA vs PAI-1 (r = 0.349, p = 0.034). Moreover, Regression analysis showed that uric acid level was independently associated with fibrinogen, INR, Hcys, ATIII, D-dimers and PAI-1 (p < 0.005). Conclusions: In hypertensive patients, SUA levels correlate significantly with blood clotting factors, possibly suggesting a prothrombotic effect of SUA in those patients.

Hypertension, Uric Acid, Blood Clotting Factors, Pro-Thrombotic Factors

Papavasileiou, M. , Aravantinos, D. , Moustakas, G. , Karamanou, A. , Patsianis, S. and Pittaras, A. (2023) Prothrombotic Effect of Serum Uric Acid in Hypertensive Patients. Open Access Library Journal, 10, 1-14. doi: 10.4236/oalib.1109567.