Author(s)

Felipe P. Perez¹, Maryam Rahmani², Jorge Morisaki³, Farhan Amran², Syazwani Bakri², Akmal Halim³, Alston Dsouza², Nurafifi Mohd Yusuff², Amran Farhan², James Maulucci², Maher Rizkalla²

¹Department of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA.
²Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA.
³Department of Bioengineering, University of Illinois at Chicago, Chicago, USA.

Alzheimer’s disease (AD) is a brain disorder that eventually causes memory loss and the ability to perform simple cognitive functions; research efforts within pharmaceuticals and other medical treatments have minimal impact on the disease. Our preliminary biological studies showed that Repeated Electromagnetic Field Stimulation (REFMS) applying an EM frequency of 64 MHz and a specific absorption rate (SAR) of 0.4 - 0.9 W/kg decrease the level of amyloid-β peptides (Aβ), which is the most likely etiology of AD. This study emphasizes uniform E/H field and SAR distribution with adequate penetration depth penetration through multiple human head layers driven with low input power for safety treatments. In this work, we performed numerical modeling and computer simulations of a portable Meander Line antenna (MLA) to achieve the required EMF parameters to treat AD. The MLA device features a low cost, small size, wide bandwidth, and the ability to integrate into a portable system. This study utilized a High-Frequency Simulation System (HFSS) in the design of the MLA with the desired characteristics suited for AD treatment in humans. The team designed a 24-turn antenna with a 60 cm length and 25 cm width and achieved the required resonant frequency of 64 MHz. Here we used two numerical human head phantoms to test the antenna, the MIDA and spherical head phantom with six and seven tissue layers, respectively. The antenna was fed from a 50-Watt input source to obtain the SAR of 0.6 W/kg requirement in the center of the simulated brain tissue layer. We found that the E/H field and SAR distribution produced was not homogeneous; there were areas of high SAR values close to the antenna transmitter, also areas of low SAR value far away from the antenna. This paper details the antenna parameters, the scattering parameters response, the efficiency response, and the E and H field distribution; we presented the computer simulation results and discussed future work for a practical model.

Alzheimer’s Disease, Meander Line Antenna, HFSS, EMF Linearity, SAR, Field Distribution

Perez, F. , Rahmani, M. , Morisaki, J. , Amran, F. , Bakri, S. , Halim, A. , Dsouza, A. , Yusuff, N. , Farhan, A. , Maulucci, J. and Rizkalla, M. (2023) Numerical Modeling and Computer Simulation of a Meander Line Antenna for Alzheimer’s Disease Treatment, a Feasibility Study. Journal of Biosciences and Medicines, 11, 177-185. doi: 10.4236/jbm.2023.112013.