Author(s)

Huabei Wu¹, Shijie Yin²

¹School of General Medical, Guangxi Medical University, Nanning, China.
²The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, China.

Objective: There are numerous studies suggesting that genetic polymor-phisms of inflammation factors Toll-like receptors 2 and 4 (TLR2, TLR4) might play a role in the pathophysiological process of hypertension. In this study, we evaluated the association in a sample of members of the Chinese Han population. Method: We selected four single nucleotide polymor-phisms (SNP) of TLR2 (rs3804099, rs3804100, rs7656411) and TLR4 (rs1927906) genes, and measured the distributions of genotypic and allelic frequencies in 1063 participants, including 391 essential hypertension pa-tients and 672 controls. Result: No significant differences in the genotypic and allelic frequencies of the four SNPs were detected between cases and controls. However, three haplotypes, CCG, TTG and TTT of TLR2, were significantly associated with a decrease in the risk of essential hyperten-sion (OR: 0.512, 95% CI: 0.397 - 0.660, P < 0.000; OR: 0.701, 95% CI: 0.550 - 0.892, P = 0.0038; OR: 0.797, 95% CI: 0.667 - 0.952, P = 0.0122, respectively). Inversely, the risk of essential hypertension increased sig-nificantly in patients with the CTG, TCG or TCT haplotypes (OR: 2.924, 95% CI: 2.157 - 3.963, P < 0.0000; OR: 3.955, 95% CI: 2.042 - 7.660, P < 0.0000; OR: 6.998, 95% CI: 4.137 - 11.838, P < 0.0000, respectively). Conclusion: Our study suggested that haplotypes (CCG, TTG, TTT, CTG, TCG and TCT) of TLR2 might have profound effects on the development of essential hypertension in the Chinese Han population.

Toll-Like Receptor 2, Toll-Like Receptor 4, Single-Nucleotide Polymor-phisms, Essential Hypertension, Inflammation

Wu, H. and Yin, S. (2023) Relationship of Toll-Like Receptors 2 and 4 Gene Polymorphisms with Essential Hypertension in Chinese Han Population. Journal of Biosciences and Medicines, 11, 53-63. doi: 10.4236/jbm.2023.112004.