Author(s)

Li Wang

The First Affliated Hospital of Xi’an Medical University, Xi’an, China.

A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.

3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[d] Isoxazole-4, 6-Diol, Synthesis, Antitumor Activity

Wang, L. (2023) Synthesis and Antitumor Activity of 3-[2-(4- Hydroxy-Phenyl)-Ethyl]-Benzo[d] Isoxazole-4,6-Diol. International Journal of Organic Chemistry, 13, 1-6. doi: 10.4236/ijoc.2023.131001.