Author(s)

Fiffou Yougbare¹, Aziz Sidi Aristide Tapsoba¹, Pegdwendé Abel Sorgho^1,2, Bagora Bayala^1,2, Lassina Traore¹, Prosper Bado¹, Bapio Valérie Elvira Jean Télesphore Bazie³, Abdou Azaque Zoure³, Esther Mah Alima Traore³, Théodora Mahoukèdè Zohoncon⁴, Sessi Frida Tovo¹, Albert Théophane Yonli^1,2, Alice Kiba⁵, Florencia Wendkuuni Djigma^1,2*, Jacques Simpore^1,2

¹Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
²Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso.
³Université Saint Thomas d’Aquin, Ouagadougou, Burkina Faso.
⁴Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
⁵Centre National de Transfusion Sanguine (CNTS), Ouagadougou, Burkina Faso.

Objective: The aim of this study was to characterize the polymorphisms of the DC-SIGN (-336 A/G, rs4804803) gene and their association with the immunopathogenicity of dengue fever in Burkina Faso. Methods: A total of three hundred forty-one subjects, patients of all ages have been included in the study: 208 persons presenting clinical signs of dengue fever which were confirmed by diagnostic and 133 Healthy Controls. Genotyping for the CD209 variant (-336 A/G, rs4804803) was carried out using TaqMan SNP Genotyping Assays. Haplotype frequencies were inferred and compared between the study groups. Results: The percentage of men was 61.88% (211/341) and 38.12% (130/341) for women. The highest frequency of dengue fever (77.42%) was noted in patients with age between 20 to 40 years. Around 1.52% of the study population was positive for HIV, 40.55% were carriers of HBV and 3.83% of HCV. Genotype distribution of the CD209 variant (-336 A/G, rs4804803) was in Hardy-Weinberg equilibrium in both patients and controls. The frequency of allele A was higher than allele G; however, statistical analyses showed that there is no significant difference in genotypes GG, AG and AA in patients and controls. Conclusion: This related no significant association with dengue for the variant of ?336 A/G in the DC-SIGN gene in an Ouagadougou population. However, our results offered the SNP frequencies in a West African population, which might be useful for the study of ethnic groups.

Dengue Virus, CD209 Variant (-336 A/G, rs4804803), Burkina Faso

Yougbare, F. , Tapsoba, A. , Sorgho, P. , Bayala, B. , Traore, L. , Bado, P. , Bazie, B. , Zoure, A. , Traore, E. , Zohoncon, T. , Tovo, S. , Yonli, A. , Kiba, A. , Djigma, F. and Simpore, J. (2023) DC-SIGN (CD209) Promoter -336 A/G Polymorphism Is Not Associated with Dengue Fever at Burkina Faso, West Africa. Journal of Biosciences and Medicines, 11, 175-183. doi: 10.4236/jbm.2023.111017.