Author(s)

Chrystiano De Campos Ferreira^1,2*, Ricardo Ribeiro Gama¹, Ana Carolina De Carvalho³, Iara Santana⁴, Raiany S. Carvalho¹, Debora S. De A. e Silva³, Lais M. De Jesus³, Rui M. Reis^3,5, Rozany Dufloth⁶

¹Department of Head and Neck Surgery, Barretos Cancer Hospital, São Paulo, Brazil.
²Department of Medicine, Federal University of Rondônia, Rondônia, Brazil.
³Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil.
⁴Department of Pathology, Barretos Cancer Hospital, São Paulo, Brazil.
⁵Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal.
⁶Institute of Anatomical Pathology, Rede D’Or São Luiz Hospitals Network, São Paulo, Brazil.

Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Human Papillomavirus (HPV). The aim of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients. Methods: We conducted a cross-sectional study on patients with OPSCC admitted to the Barretos Cancer Hospital, Brazil from 2014 to 2019. Of these, DNA extraction was performed on 40 patients and genetic ancestry was assessed using a specific panel of 46 informative ancestry markers. Results: We observed a predominance of European ancestry (63%), followed by African (18%), Amerindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group. We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Amerindian (p = 0.836) ancestry. Conclusions: We found a predominance of European ancestry, both in the HPV-positive and HPV-negative groups. In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.

Oropharyngeal Neoplasms, Genetic Ancestry, HPV, Head and Neck Neoplasms, P16

Ferreira, C. , Gama, R. , De Carvalho, A. , Santana, I. , Carvalho, R. , e Silva, D. , De Jesus, L. , Reis, R. and Dufloth, R. (2023) Role of Genetic Ancestry in Oropharyngeal Squamous-Cell Carcinoma: A Cross-Sectional Study in Brazil. Journal of Biosciences and Medicines, 11, 150-161. doi: 10.4236/jbm.2023.111015.