Author(s)

David Ntiamoah Ofosu^1,2*, Akwasi Asamoah¹, Ransford Mawuli Tuekpe¹, Edmond Opoku Addo¹, Elijah Kofi Takyi¹, Alex Addai¹

¹Department of Basic and Applied Biology, School of Sciences, University of Energy and Natural Resources, Sunyani, Ghana.
²Department of Medical Diagnostics, Faculty of Allied Health Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: In Ghana, the use of Chromolaena odorata (Acheampong Leaf) as a first aid material to control bleeding is a very common practice in the rural areas. This study sought to assess the coagulation effect of aqueous extract of C. odorata (Acheampong Leaf) leaves on the coagulation profile. Methods: In this experimental study, freshly obtained C. odorata leaves extract was made using distilled water. Blood samples were taken from 197 non-hemophiliacs. PT and aPTT tests were tested with the extract. Results: The study result showed significantly reduced PT results of the study participants (17.89 ± 3.06 s to 16.43 ± 2.51 s, p < 0.0001) but no effect was recorded with aPTT (38.83 ± 7.13 s against 39.12 ± 7.85, p = 0.709). Conclusion: C. odorata proved to be strongly effective in promoting coagulation (procoagulant) in vitro. We recommend studies to isolate and purify the active chemical compound in C. odorata leaves to further the pathway and mechanism of action.

C. odorata, Acheampong Leaf, Prothrombin Time, Activated Partial Thromboplastin Time

Ofosu, D.N., Asamoah, A., Tuekpe, R.M., Addo, E.O., Takyi, E.K. and Addai, A. (2023) Assessing the Effect and Use of an Aqueous Form of a Common Ghanaian Leaves Extract, Chromolaena odorata (Acheampong Leaf) on Coagulation Test Parameters in Vitro. Open Access Library Journal, 10, 1-12. doi: 10.4236/oalib.1109611.