Author(s)

Chaojie Zhang^1*, Ke He^2*, Caixia Li^2#, Yazhen Shang^1#

¹Institute of Traditional Chinese Medicine, Chengde Medical College/Hebei Province Key Research Office of Traditional Chinese Medicine against Dementia/Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development/Hebei Key Laboratory of Nerve Injury and Repair, Chengde, China.
²The Fourth Hospital of Shijiazhuang, Shijiazhuang, China.

Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in the control group were intraperitoneally injected with saline, while those in the solvent control group were intraperitoneally injected with DMSO + sulfobutyl-β-cyclodextrin solvent, and those in the BI-D1870 group were intraperitoneally injected with BI-D1870. All the rats’ appearance and behavior were daily observed, and body weight was recorded on the day 15, 30, 45, 60, 75 and 82 of BI-D1870 injected. Morris water maze was used to screen the rats’ learning and memory acquisition ability on the day 22 - 25, 52 - 55, and 82 - 85 of training by BI-D1870 treated. The successful rates of the rats’ memory impairment were respectively calculated for three times screening. Results: During the whole experiment, there was no obvious difference in appearance and fur color in all rats. The rats’ agitation began to appear on the day 10th of BI-D1870 given. The agitation rats’ number and rats’ body weight gradually increased along with BI-D1870 treated (P < 0.05, P < 0.01). According to the latency of rats on the day 25, 55 and 85 in Morris water maze training, the rats’ successful rate in the learning and memory acquisition ability impairment induced by BI-D1870 was 50.00%, 62.00% and 82.00%, respectively. Conclusion: Intraperitoneal injection of BI-D1870 can induce the rats’ learning and memory acquisition ability disorder.

BI-D1870, Learning and Memory Acquisition Impairment, Morris Water Maze, RSK Inhibitor

Zhang, C. , He, K. , Li, C. and Shang, Y. (2023) BI-D1870 Causes the Rats’ Learning and Memory Acquisition Ability Impairment. Journal of Biosciences and Medicines, 11, 82-97. doi: 10.4236/jbm.2023.111009.