Timed Intercourse versus Intrauterine Insemination with Mild Ovarian Stimulation for Unexplained Infertility ()
ABSTRACT
Background: Infertility is unexplained in about 22% - 28% of infertile couples. Spontaneous pregnancy may occur in them. If did
not happen, Expectant management will be via clomiphene citrate (CC)
administration, intrauterine insemination (IUI), and IVF & ICSI. Aim: to assess the effectiveness of intrauterine
insemination with mild controlled ovarian stimulation compared with expectant
management in couples with unexplained infertility more than one year. Methods: 160 couples with unexplained
infertility were selected, The couples were randomly divided into two groups:
Group (A) “80 couples”: Intrauterine insemination (IUI) with mild controlled
ovarian stimulation (combination of CC + hMG) using prepared semen and was performed 36 hours after hCG injection,
Group (B) “80 couples”: Couples had no ovulation induction. They encouraged for
timed intercourse in the most fertile days of female cycle guided by
folliculometry for 6 months. Data were collected quantitatively, coded and
analyzed using SPSS. The power of study is 80% and 95% confidence interval. Result: The pregnancy rate was
calculated in both groups: In group (A) (IUI/COS): OPR (Ongoing pregnancy rates) was 27.5% and PR (pregnancy rates)/cycle was 8.6%. In group (B)
(Expectant management): OPR was 25% and PR/cycle was 5.3%. Conclusion: Mild controlled ovarian
stimulation CC + hMG with IUI offers no statistical significance in terms of pregnancy outcomes over expectant management in
this study however significance in the response to stimulation.
Share and Cite:
Hamid, H. , Alsayed, M. , Hamed, H. and Belal, S. (2022) Timed Intercourse versus Intrauterine Insemination with Mild Ovarian Stimulation for Unexplained Infertility.
Open Journal of Obstetrics and Gynecology,
12, 1279-1288. doi:
10.4236/ojog.2022.1212112.
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