Humoral Response to Toxoplasma gondii in Pregnant Women in Bangui Central African Republic ()
ABSTRACT
Toxoplasmosis is a cosmopolitan antrhropozoonosis widespread in mammals
and birds. Normally asymptomatic in the subject health, it can have serious
consequences for the fetus in the first
trimester of pregnancy in the pregnant woman. It is in this context that we
propose to assess the immune response to T.
gondii in pregnant women in Bangui. This was a retrospective analytical
study that consulted the records of pregnant women received in prenatal
consultations at the Bangui Community Hospital Maternity ward from January 2019
to December 2019. Socio-demographic and laboratory data (IgM, IgG response to T. gondii) and results of HIV serology
were collected from January to June 2021. Chi2 test was used. A
total of 307 pregnant women were analyzed. The average age of the women
included was 28 (±6) years. The average parity of the entire sample was 2.18
(±1.93). Toxoplasmosis infectious was 14.65%. Women with a positive IgM
response accounted for 17.58% and those with an IgG-positive response for
42.99%. Patients with a positive HIV were 5.86%. Patients aged 20 - 29 had a serological profile suggesting a probable
ongoing infection (p = 0.010). The paucipares were more represented with no
statistically significant difference (p = 0.23). Pregnant women were not
significantly exposed to toxoplasmosis infectious (p = 0.96). Immunized and
non-immunized subjects were similarly exposed [OR = 0.97; CI 95% 0.4 = 6 - 2.05]. Toxoplasmosis remains particularly serious
during pregnancy. Seroprevalence was significantly higher in the 20 - 24 year age group. Women were similarly exposed
depending on whether they were immunized or not. This requires the
establishment of a specific prevention program against this disease.
Share and Cite:
Nambei, W. , Nguerenam, J. , Kodia-Lenguetama, E. and Gbamonza, A. (2022) Humoral Response to
Toxoplasma gondii in Pregnant Women in Bangui Central African Republic.
Open Journal of Immunology,
12, 122-129. doi:
10.4236/oji.2022.124008.
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