Author(s)

Amadou Djibrilla-Almoustapha^1,2*, Moustapha Mamane-Brah³, Moustapha Elhadj-Chefou⁴, Maman Rabiou Badé¹, Faiza Abba-Ousmane¹, Fanta Ousseini¹, Oumoulkairou Abdoulaye-Soumana¹, Badé Malam-Abdou^1,2

¹Departement of Onco-Hematology of the National Hospital of Niamey, Niamey, Niger.
²Faculty of Health Science, Abdou Moumouni University of Niamey, Niamey, Niger.
³Faculty of Health Science, André Salifou University of Zinder, Zinder, Niger.
⁴Faculty of Health Science of Maradi, Maradi, Niger.

Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation; the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient’s prognosis.

Chronic Lymphocytic Leukemia, Young Subject, del 17 p, HNN, Niger

Djibrilla-Almoustapha, A. , Mamane-Brah, M. , Elhadj-Chefou, M. , Badé, M. , Abba-Ousmane, F. , Ousseini, F. , Abdoulaye-Soumana, O. and Malam-Abdou, B. (2022) Chronic Lymphocytic Leukemia of del 17p in a Young Subject: About a Case and Reviewed a Literature. Open Journal of Blood Diseases, 12, 103-109. doi: 10.4236/ojbd.2022.124011.